Abstract
Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage. Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines. Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL. Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure.
Highlights
Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones
Our findings revealed that ESWL causes inflammation in the urinary system and this rising trend of inflammation lasts within 14 days
According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation continues to increase up to 14 days after procedure
Summary
Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage. Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL. Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure. Extracorporeal shock wave lithotripsy (ESWL) was primarily used for medical intentions in the 1980s and established the dramatic effect on the treatment of urinary stones. The major impact of ESWL is on the stones located in middle calyx, upper calyx and renal pelvis respectively. Among stones of different types, uric acid and struvite are Original
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