Abstract
Bupropion hydrochloride (HCI) is an antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor and has three different dosage forms including immediate release (IR), sustained release (SR), and extended release (ER). Despite its relatively safe side effect profile bupropion may cause several side effects. Here, we aimed to report a case with major depression using extended release form of bupropion hydrochloride who was presented with urinary incontinence during sleep, an uncommon side effect of bupropion.
Highlights
Bupropion is a second-generation antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor [1]
Bupropion has immediate release, sustained release, and extended release forms which are used in quitting smoking and extended release form is used in major depressive disorder in our country [2, 3]
Selective serotonin reuptake inhibitors (SSRIs) may cause urinary incontinence as a side effect and it is seen that serotonin/noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants may decrease present urinary incontinence symptoms
Summary
Bupropion is a second-generation antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor [1]. Bupropion is considered safe in terms of the side effect profile and is found to cause less sexual dysfunction, sedation, sleep, and weight gain [4]. The underlying mechanism is not fully known, it may involve relaxation of the bladder wall with noradrenergic and anticholinergic effects and changes in the urethral perfusion [6, 7]. By presenting this case of urinary incontinence during sleep associated with extended release form of bupropion, we aimed to mention a side effect which is not frequently encountered in literature
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