Abstract
Pituitary gonadotropic activity was assayed biologically in rhesus and stump-tail monkeys, the hamadryas baboon and the chimpanzee. HCG-augmentation was found to increase the sensitivity of the mouse uterine weight method sufficiently to enable “general gonadotropin” measurements (i.e., measurements not specific for FSH or LH) to be secured readily in all categories of animals. Specific methods for the determination of FSH and LH yielded barely detectable values in pools comprising several days' urine of the rhesus and stump-tail monkeys and the baboon. In the adult female chimpanzee, the FSH and LH content of serial 24-hr specimens approximated human levels. The FSH values were maximal during the early follicular phase, fell below the extinction point of the assay during midcycle and became measurable again during the luteal phase. LH was excreted in a surge, the rise commencing on the day after sex skin swelling reached its zenith. (Endocrinology84: 508, 1969)
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