Abstract
Urinary free cortisol (UFC) has been shown to be a reliable measure of adrenocortical secretion, and it is generally accepted as being an index of the free fraction in the plasma. However, the interpretation of UFC results reportedly can be compromised when the urine volume in patients is considerably increased because a high fluid intake (5 L/day) increases UFC in healthy subjects (1) and UFC was reported to be closely related with the changes in urine volume in women (2). The aim of this work was to determine whether short-term changes in urine volume influence UFC. I studied 15 volunteers (6 women and 9 men) with normal body mass indexes (23.9 ± 1.9 kg/m …
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