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Abstract
After intraperitoneal injection of [ 3H]aflatoxin B 1 in rats and hamsters, 24-h urinary excretion of aflatoxin B 1 metabolites was examined in these species. Total excretion was 10–15% of the injected dose with hamster excreting 50% more than the rat. In both species, 60% of the total excretion was due to glucuronide and sulfate conjugates of hydroxy metabolites. Striking differences were observed in the excretion of both aflatoxin B 1-diol and various thiol conjugates. Aflatoxin B 1-glutathione and aflatoxin B 1-cysteinylglycine were major thiol conjugates in rats and hamsters, respectively. An unknown metabolite believed to be mercapturic acid ( N-acetylcysteine conjugate) of aflatoxin B 1 was excreted by both species, hamster excreting twice as much as the rat.
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