Abstract
The urinary excretion of androsterone (A), aetiocholanolone (E) and 17-hydroxycorticosteroids (17-OHCS) and the A/E ratio have been measured in 22 male hospital controls, 14 men with gastric ulcer, 22 men with cancer of the stomach and 14 men with cancer of the rectum before and after surgery, and also in 25 normal men. There were no significant differences in the excretion patterns of normal men, hospital controls and patients with gastric ulcer. The stomach cancer patients excreted less A ( P < 0.004) and E ( P < 0.02) and had a lower A/E ratio ( P < 0.05) than the hospital controls before surgery. After surgery the excretion pattern was not significantly different from the postoperative values for the hospital controls. The rectum cancer patients excreted less A ( P < 0.004) and had a lower A/E ratio ( P < 0.01) than hospital controls before surgery, but after surgery excreted less A ( P < 0.001) and E ( P < 0.02) and had a lower A/E ratio ( P < 0.01) than the postoperative hospital controls.
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