Abstract
The interaction between tubular epithelial cells and calcium oxalate crystals or oxalate ions is a very precarious event in the lithogenesis. Urine contains ions, glycoproteins and glycosaminoglycans that inhi bit the crystallization process and may protect the kidney against lithogenesis. Hundred patients (24 women and 76 men) with a history of stone disease and hundred controls (25 women and 75 men) were evaluated for urinary GAG concentration. By using a new dye-binding assay, the total GAG concentration in the urine was measured and corrected to urinary creatinine levels (milligram of GAG per gram creatinine). There was a preponderance of urinary stones in males ; the highest incidence being in Group 2. Excretion of GAGs in 24-hour urine sample was significantly lower in patients compared to controls, for males in all age groups and for females, however, there was no statistically significant difference in the urinary GAGs value between males and females in a given age group for either controls or patients. The urinary GAGsexcretion idecreased with age in controls, but the levels in patients were lower. Conclusion: This study shows that low urinary GAGsareassociated with urinary stones in patients.Our studylead us to propose that urinary GAG may play an important role in
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