Abstract
Injection of a “long-acting” synthetic adrenocorticotrophin [(1–24) ACTH, 20 IU/animal] into Mongolian gerbils resulted in a 3.1 fold increase of urinary free testosterone excretion over 2 days. It was accompanied by an elevation of urinary free progesterone (2.1fold), 17-hydroxyprogesterone (2.5fold), DHEA (2.8fold) and androstenedione (3.0fold) excretion. Similarly, administration of human chorionic gonadotrophin (HCG, 100 IU/animal) increased urinary excretion of free testosterone (2.3fold), progesterone (4.1fold), 17-hydroxyprogesterone (2.9fold), DHEA (4.6fold), androstenedione (5.4fold) and of estradiol (2.9fold). Data presented in this work show that the measurement of urinary free steroid excretion represents a reliable index for the secretory activity of the adrenal-gonadal-axis, and that it may in some aspects be more practicable than the measurement of steroid plasma levels, especially in small laboratory animals, enabling us to monitor the excretion of various steroids over longer time periods without stressing the animals by handling/ or blood sampling.
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