Abstract
The free histamine excreted in the urine during the first 24 hours of life was assayed fluorimetrically in normal babies, in babies who had developed the respiratory distress syndrome, and babies who had been asphyxiated at birth. Histamine excretion was shown to be unrelated to gestational age, birth-weight, volume of urine voided, and creatinine excretion, and to have a logarithmically normal distribution in the populations studied. Babies with the respiratory distress syndrome and babies with a history of birth asphyxia excreted statistically significantly greater amounts of free histamine during the first 24 hours of life than healthy infants. But there was no significant difference in histamine excretion between the group of babies with respiratory distress and the group with birth asphyxia.
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