Abstract
Urinary excretion of estriol and 15α-hydroxyestriol (estetrol) was determined in 89 women whose pregnancies were complicated by toxemia, diabetes mellitus, Rh isoimmunization, intrauterine fetal death, or recurrent intrahepatic cholestasis of pregnancy. More than 300 urine samples were analyzed by a highly specific gas chromatographic method and the results were compared with values during normal pregnancies. The 2 estrogens usually gave the same correct information on the fetal state. In some cases of toxemia, the amount of estetrol was more reliable for monitoring the intrauterine fetal condition than that of estriol. In pregnancies complicated by Rh isoimmunization, the urinary excretion of estetrol bore a linear correlation to the cord blood hemoglobin concentration. The amount of estriol in the same maternal urine samples showed no correlation with the cord hemoglobin.
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