Abstract
In a feasibility study, 25-mg. single oral doses of ephedrine sulfate, in the form of a commercial syrup and two commercial capsules, were administered in crossover fashion to three nonsmoking male subjects. Urinary pH was not controlled, but adequate urinary flow rates were maintained by regulated water intake. Urinary excretion of ephedrine was measured over a 48-hr. period by a GC method. There were no significant differences in average amounts of ephedrine excreted during any of the 11 sampling intervals, in average peak excretion rates, nor in average times of occurrence of the peak excretion rate. There were insufficient subjects used in this preliminary study to form definite conclusions about differences between or among dosage forms. The urinary excretion data were adequately described by the two-compartment open model with first-order absorption and lag time. The average elimination half-life of ephedrine was 5.99hr. estimated from the β-values obtained by exponential fitting. Average urinary pH was 6.30 (95 of the 99 samples fell within 5.32 to 7.28). The data provided little, if any, evidence of significant relationships between deviations of observed from theoretical excretion rates of ephedrine and urinary pH, urinary excretion rates of ephedrine and urinary pH, or excretion rates of ephedrine and urinary flow rates.
Published Version
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