Urinary Excretion of Cyclic AMP and Cyclic GMP in Primary Hyperparathyroidism with Reference to Clinical Signs and Symptoms

Abstract

35 patients with surgically proven primary hyperparathyroidism (PHPT) were evaluated with regard to urinary cyclic AMP and cyclic GMP excretion. They showed no signs of bone disease or impaired renal function. Preoperatively, cyclic AMP was increased in 28 patients (80%). Mean excretory value for the whole group was 8.5 ± 0.8 micromoles/g creat/24 hours, compared with controls, 4.2 ± 0.13 micromoles/g creat/24 hours. Cyclic AMP excretion was normalized after surgery.