Abstract
In TS controversial results are published on urinary excretion of androgen metabolites. Therefore we investigated the 24 h urinary excretion of 8 androgen metabolites (C19 steroids) by 8 TS patients (45,XO) (group A) compared to 17 healthy girls (group B). Bone ages (BA): (median range); A:12.1, 7.2-13.5, B:12.5, 7.2-15.9 yrs, respectively. The method used consisted of Sep-Pak extraction, enzymatic hydrolysis, derivative formation and capillary column gas chromatography. Results: The excretion of total C19 steroids was not different in A and B before as well after BA of 10 years. Before: A=1.5±0.2, B=1.3±0.4, after: A=2.7±1.2, B=1.7±0.9 [mg/m2/24 h]. Also individual C19 steroids showed no differences between A and B before BA of 10 years. After BA of 10 years, however, in TS the urinary contents of DHA and androstenetriol-16α were significantly (p 10yrs the elevated excretion of DHA and androstenetriol-16α is probably due to either lack of conversion to testosterone or to increased adrenal synthesis. Supported by DFG (Ho-471).
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