Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders.

Tatsuya Yamamoto,Masato Asahina,Yoshitaka Yamanaka,Ryuji Sakakibara,Shogo Furukawa,Satoshi Kuwabara,Fuyuki Tateno,Miki Fuse,Tomoyuki Uchiyama,Mitsuru Yanagisawa,Yasuko Koga,Shigeki Hirano,Jong-Ling Fuh

doi:10.1371/journal.pone.0149278

Abstract

BackgroundAutonomic urinary dysfunction affects patients with progressive supranuclear palsy (PSP); however, the severity and prevalence of urinary dysfunctions in these patients compared with those observed in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA) are unknown.ObjectiveWe compared urinary dysfunction characteristics in patients with PSP, PD, and MSA.Patients and MethodsForty-seven patients who satisfied the probable or possible criteria of the National Institute for Neurological Diseases and Stroke and Society for PSP were assessed using the urinary symptoms questionnaire and the urodynamic study at Chiba and Toho Universities (n = 26 and 21, respectively). The results were compared with those of patients with PD and MSA (n = 218 and 193, respectively).ResultsThe mean disease duration of PSP and the mean age were 2.97 ± 0.26 and 71.4 ± 0.88 years, respectively. The mini-mental state examination and frontal assessment battery scores were 22.6 ± 0.70 and 10.7 ± 0.49, respectively. Urinary storage and voiding symptoms were observed in 57% and 56% of patients with PSP, respectively. Detrusor overactivity in the urodynamic study was detected in 81% of patients with PSP, which was slightly more than that found in patients with PD (69%) and MSA (67%); however, this was not statistically significant. Postvoid residual volume in patients with PSP was significantly more than that in patients with PD (P < 0.01), but was equivalent to that in patients with MSA.ConclusionsThe present study demonstrated that patients with PSP experienced various urinary dysfunctions. Urinary storage dysfunction in patients with PSP was not different from that in patients with PD or MSA, whereas urinary voiding dysfunction in patients with PSP was milder than that in patients with MSA and more severe than that in patients with PD. These features should be taken into account for the differentiation of PSP from PD and MSA.

Highlights

Progressive supranuclear palsy (PSP) is a neurodegenerative disease clinically characterized at onset by impaired balance, slowness in movement, subtle personality changes, such as apathy and disinhibition, impairment in executive functioning, bulbar symptoms, and impaired eye motion [1]
Detrusor overactivity in the urodynamic study was detected in 81% of patients with PSP, which was slightly more than that found in patients with Parkinson’s disease (PD) (69%) and multiple system atrophy (MSA) (67%); this was not PLOS ONE | DOI:10.1371/journal.pone
The present study demonstrated that patients with PSP experienced various urinary dysfunctions

Summary

Introduction

Progressive supranuclear palsy (PSP) is a neurodegenerative disease clinically characterized at onset by impaired balance, slowness in movement, subtle personality changes, such as apathy and disinhibition, impairment in executive functioning, bulbar symptoms, and impaired eye motion [1]. These symptoms are typically heterogeneously presented in patients with PSP. Autonomic urinary dysfunction affects patients with progressive supranuclear palsy (PSP); the severity and prevalence of urinary dysfunctions in these patients compared with those observed in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA) are unknown

Methods

Results

Conclusion