Abstract
The authors compared catecholamine concentrations measured on 2‐hour urine collections of recently hospitalized cocaine abusers (CAs; n = 17) with those of detoxified alcoholic patients (APs; n = 10) and staff normal‐control subjects (NCs; n = 13). CAs had been abstinent for 6–8 days; APs had been abstinent for 9–53 days. Compared with NCs, the recently abstinent CAs had a decrease in the dopamine metabolite, 3,4‐dihydroxyphenylacetic acid (DOPAC), and a decrease in Sum dopamine/Sum norepinephrine (the molar sum of dopamine and its metabolites/the molar sum of norepinephrine and its metabolites). The dopamine metabolite, 3‐methoxytyramine (3‐MT) was increased. The detoxified APs had increases in the norepinephrine metabolites normetanephrine and 3‐methoxy‐4‐hydroxyphenylglycol in addition to elevated 3‐MT. Sum dopamine/Sum norepinephrine was decreased in APs compared with NCs. The authors discuss differences in light of other findings related to recent abstinence after cocaine and alcohol abuse.
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