Abstract
THE BIOTRANSFORMATION of drugs takes place mainly in the smooth endoplasmic reticulum of the liver. Some individuals, particularly children, have unusual drug responses or idiosyncrasies to various antiemetic drugs, e.g., phenothiazines and their derivatives 1, 2 and metodopromide, 3 and develop extrapyramidal signs and dystonic reactions. These extrapyramidal reactions are caused by an unusual sensitivity to the drugs. These individuals may have an inherited defect involving the hepatic detoxification of the drugs?' 3 Recently measurement of 24-hour urinary excretion of D-glucaric acid has been used as an index of the enzymatic activity of the smooth endoplasmic reticulum of the liver? -* In this paper the experiences with seven children who developed alarming reactions to recommended doses of various antiemetic drugs are presented.
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