Urinary Cystatin C as an Early Biomarker of Acute Kidney Injury after Open and Endovascular Abdominal Aortic Aneurysm Repair

Abstract

Acute kidney injury (AKI) after open repair (OR) and endovascular repair (EVAR) of abdominal aortic aneurysm (AAA) is associated with increased mortality and hospital costs. Early detection of AKI is critical to prevent its progression. Recent findings demonstrate that elevated levels of urinary cystatin C (uCysC) may reflect tubular dysfunction. We prospectively evaluated whether uCysC can detect renal dysfunction earlier than serum creatinine (sCr). In a prospective study, 126 consecutive patients (mean age±SD, 69.1±8.66years) with AAA (EVAR=87, OR=39) were enrolled. sCr and uCysC were measured preoperatively (baseline) and at 6, 24, and 48hr postoperatively. A final measurement was made on day 5. AKI was defined according to Acute Kidney Injury Network criteria. The incidence of AKI was significantly higher (χ(2) test, P<0.05) in the OR group (n=13, 33%) than in the EVAR group (n=15, 17%). The baseline median (interquartile range) value of uCysC was significantly higher (t-test, P<0.05) in patients of both groups (OR-EVAR) who developed AKI from those who did not (OR/AKI group: 0.06 [0.02-0.12] mg/L, EVAR/AKI group: 0.08 [0.05-0.11] mg/L versus no-AKI subjects: 0.04 [0.02-0.07] mg/L). Subsequent analysis showed that at 6hr postoperatively, the patients who developed AKI increased their uCysC levels significantly from baseline (OR/AKI group: 0.58 [0.42-0.70] mg/L, EVAR/AKI group: 0.59 [0.30-1.07] mg/L). The median value of uCysC in AKI patients increased at 24hr (OR/AKI group: 1.37 [0.78-3.40] mg/L, EVAR/AKI group: 2.11 [0.70-2.42] mg/L) and peaked at 48hr (OR/AKI group: 6.16 [1.74-10.73] mg/L, EVAR/AKI group: 2.57 [1.21-7.40] mg/L), while no increase was observed among those who did not develop AKI at the same time points (0.06 [0.04-0.14] vs. 0.08 [0.04-0.19] mg/L). The diagnostic accuracy of uCysC at 6hr post-surgery was excellent (area under the curve - receiver-operating characteristic [AUC-ROC]=0.968), significantly higher than sCr (AUC-ROC=0.844) and a cutoff value set at 0.30mg/L can diagnose AKI with a sensitivity of 85.71% and a specificity of 98.97%. uCysC is superior to sCr in the early diagnosis of AKI following open and endovascular AAA repair.