Urinary biomarkers in patients with detrusor underactivity with and without bladder function recovery.

Abstract

Detrusor underactivity (DU) is frequently encountered in elderly patients. Part of patients with DU might have bladder function recovery after treatment. This study investigated urinary proteins in these DU patients with and without bladder function recovery. A total of 37 patients with chronic urinary retention and urodynamically proven DU were enrolled. After treatment, 24 DU patients had bladder function recovery whereas 13 had not, after 1-year follow-up. Urine collection at baseline was performed, and the urinary protein including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and prostaglandin E2 (PGE2) were measured by ELISA. Twenty urodynamically normal, 34 detrusor overactivity (DO) and 15 detrusor hyperactivity and inadequate contractility (DHIC) patients served as comparative groups. Urinary NGF levels were significantly higher than normal in patients with DU (9.2±20.3 vs 1.85±2.9pg/ml, p=0.037). Urinary BDNF level was only significantly higher in patients with DU than that of the control group (153±199 vs 77.4±47.7pg/ml, p=0.033) but not in patients with DHIC or DO. Compared with the control group, the urinary BDNF level was significantly higher in DU patients with bladder function recovery (190±239pg/ml, p=0.033) but not in patients without recovery (85.8±43.7pg/ml, p=0.612). The PGE2 level was significantly higher than the control group in DU patients with bladder function recovery (1290±836pg/ml, p<0.0001) but not in patients without recovery (383±237pg/ml, p=0.130). Patients with DU and higher urinary PGE2 and BDNF levels might have a chance to recover bladder function than those with a lower protein level.