Abstract
Background: Bile alcohols are normal constituents of urine. Methods: To better understand bile alcohol profile in childhood, urinary specimens from 41 healthy children and 10 children with cholestasis, and 3 healthy adults, were analyzed by GLC and GC-MS. Results: Five bile alcohols, 27-nor-5β-cholestane-3α,7α,12α,24S,25R-pentol, 5β-cholestane-3α,7α,12α,24S, 25-pentol, 5β-cholestane-3α,7α,12α,24S,26-pentol, 5β-cholestane-3α,7α, 12α,25,26-pentol, and 5β-cholestane-3α,7α,12α,26,27-pentol were identified in all specimens. C 26-Pentol was the most abundant constituent, constituting 29.5 to 65% of bile alcohols. Among healthy children ( n=41), no significant relationship was seen between proportions of the C 26-pentol and age, but older children ( n=15, 6 to 14 years) showed a significantly greater mean percentage of the C 26-pentol than young children ( n=26, 0 to 5 years; 58.1±4.23% vs. 46.0±9.24%, p<0.001). In children with cholestatic liver diseases, the percentage of C 26-pentol in urinary bile alcohols was significantly lower than age-matched controls. Conclusions: There is an increased composition of C 26-pentol in older children and relatively decreased composition of C 26–pentol in children with cholestatic liver diseases.
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