Urinary arsenic metabolites of subjects exposed to elevated arsenic present in coal in Shaanxi Province, China.

Jianwei Gao,Linsheng Yang,Jiangping Yu

doi:10.3390/ijerph8061991

Abstract

In contrast to arsenic (As) poisoning caused by naturally occurring inorganic arsenic-contaminated water consumption, coal arsenic poisoning (CAP) induced by elevated arsenic exposure from coal combustion has rarely been reported. In this study, the concentrations and distributions of urinary arsenic metabolites in 57 volunteers (36 subjects with skin lesions and 21 subjects without skin lesions), who had been exposed to elevated levels of arsenic present in coal in Changshapu village in the south of Shaanxi Province (China), were reported. The urinary arsenic species, including inorganic arsenic (iAs) [arsenite (iAsIII) and arsenate (iAsV)], monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV), were determined by high-performance liquid chromatography (HPLC) combined with inductively coupled plasma mass spectroscopy (ICP-MS). The relative distributions of arsenic species, the primary methylation index (PMI = MMAV/iAs) and the secondary methylation index (SMI = DMAV/MMAV) were calculated to assess the metabolism of arsenic. Subjects with skin lesions had a higher concentration of urinary arsenic and a lower arsenic methylation capability than subjects without skin lesions. Women had a significantly higher methylation capability of arsenic than men, as defined by a higher percent DMAV and SMI in urine among women, which was the one possible interpretation of women with a higher concentration of urinary arsenic but lower susceptibility to skin lesions. The findings suggested that not only the dose of arsenic exposure but also the arsenic methylation capability have an impact on the individual susceptibility to skin lesions induced by coal arsenic exposure.

Highlights

Arsenic (As) is a ubiquitous element in environment
MMAV and DMAV are less toxic than inorganic arsenic (iAs) [6,7], the existence of trivalent intermediates, monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII) during the arsenic metabolism process has been confirmed [8]
Within the context of the perspectives mentioned above, the objectives of our study were: (1) to investigate the profile of urinary arsenic metabolites in residents exposed to coal arsenic in the south of Shaanxi Province (China); (2) to find out the relationship between urinary arsenic metabolites and skin lesions induced by chronic arsenic exposure; (3) to evaluate the effect of sex and age on urinary arsenic metabolites and arsenic methylation capability

Summary

Introduction

Arsenic (As) is a ubiquitous element in environment. An established association between human chronic arsenic exposure and a variety of health outcomes, including skin diseases, diabetes, peripheral vascular disease and kinds of cancers [1,2,3,4,5], has been known for many years. MMAV and DMAV are less toxic than iAs [6,7], the existence of trivalent intermediates, monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII) during the arsenic metabolism process has been confirmed [8]. They are formed by the reduction of MMAV and DMAV and are more toxic than iAs. They are formed by the reduction of MMAV and DMAV and are more toxic than iAs Petrick and his colleagues have proposed the following order of toxicity of arsenicals in Chang human hepatocytes: MMAIII > arsenite > arsenate > MMAV = DMAV [7]

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Results

Conclusion