Abstract
Background: NAFLD is the most common cause of CLD worldwide with definite diagnosis based on Liver Biopsy. Recent studies have provided a strong insight into the liver kidney cross talk between NAFLD and CKD. Alpha-1 Microglobulin (A1M) is a glycoprotein secreted by liver. Glomeruli freely filter the unbound form of A1M, then reabsorbed and broken down by proximal tubular epithelial cells. Hence elevated A1M levels in urine strongly suggest defective reabsorption capacity of proximal tubules indicating kidney function decline.
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