Abstract
In this commentary, we discuss a study conducted by Ohisa et al., in which the sensitivity and specificity of different approaches to differentiating glomerular from nonglomerular hematuria were compared. Urine specimens (n = 579) from patients with microscopic hematuria of known origin were evaluated both morphologically (by use of phase-contrast microscopy) and biochemically (by calculation of urinary albumin:total protein, albumin:creatinine, and total protein:creatinine ratios). The study showed that the albumin:total protein ratio had the highest sensitivity and specificity for identifying glomerular hematuria (97.3% and 100%, respectively). We highlight important limitations of the study and question whether the results can be generalized to patients with asymptomatic hematuria.
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