Abstract
Urinary excretion of 3-methylhistidine (3-MH) was evaluated as an indicator of dietary protein quality using adult rats with shortterm feeding. The effect of protein depletion and repletion on excretion of 3-MH was also studied. Four groups of 6 rats weighing between 250 and 300 grams were fed diets containing 10% protein from casein, wheat gluten, blood globin, or a complementary mixture of wheat gluten and globin. Daily variations of weight, 3-MH and creatinine, as well as 6-day means were observed. The correlation of PER with the 6-day means of urinary 3-MH was not high. Body weight changes and fractional rates of synthesis (based on estimated myofibrillar 3-MH pool size) appeared to be highly correlated to PER and sensitive to the influence of dietary protein and calorie deficiencies on body protein metabolism. 3-MH excretion, then, when used to determine fractional rates of catabolism and synthesis of myofibrillar protein, could be useful in short-term protein evaluation using adult rats.
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