Abstract
Background: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence and prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. The current study aimed to provide additional evidence on the incidence of acute kidney injury (AKI) in COVID-19 patients and propose the use of urinalysis as a tool for screening kidney impairment. Methods: 178 patients with confirmed COVID-19 were enrolled in this retrospective cohort study. The laboratory examinations included routine blood tests, blood biochemical analyses (liver function, renal function, lipids, and glucose), blood coagulation index, lymphocyte subset and cytokine analysis, urine routine test, C-reactive protein, erythrocyte sedimentation, and serum ferritin. Results: No patient exhibited a rise in serum creatinine or Cystatin C and occurrence of AKI, and only 2.8% of patients were recorded with an elevated level of blood urea nitrogen among all cases. On the contrary, 54.2% of patients who underwent routine urine testing presented with an abnormal urinalysis as featured by proteinuria, hematuria, and leucocyturia. Conclusions: Kidney impairment is prevalent among COVID-19 patients, with an abnormal urinalysis as a clinical manifestation, implying that a routine urine test is a stronger indication of prospective kidney complication than a blood biochemistry test.
Highlights
Since its outbreak in 2019, Coronavirus 2019 (COVID-19), caused by the new severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly swept over the globe, resulting in a global pandemic
There have been over 279 million confirmed cases of COVID-19 as of 27 December 2021, with 5.3 million deaths reported to the WHO, placing a tremendous economic and medical burden on the world
A total of 178 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled in this study, among which 52 patients were from ICU, and 126 patients were from ordinary isolation wards
Summary
Since its outbreak in 2019, Coronavirus 2019 (COVID-19), caused by the new severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly swept over the globe, resulting in a global pandemic. There have been over 279 million confirmed cases of COVID-19 as of 27 December 2021, with 5.3 million deaths reported to the WHO, placing a tremendous economic and medical burden on the world. The probability of major complications and death in COVID-19 patients increases with age, especially in persons with metabolic syndrome, type 2 diabetes mellitus, and some other serious chronic diseases, which are considered to be risk factors for the severe course of COVID-19 [5–8]. Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. In COVID-19 patients and propose the use of urinalysis as a tool for screening kidney impairment The current study aimed to provide additional evidence on the incidence of acute kidney injury (AKI)
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