Abstract
Uridine phosphorylase activity was assayed in heart extracts from rats of different postnatal age. Activity was low at birth, increased to a maximum at 8--14 days of postnatal development and then decreased to a low adult level. The switch from cellular hyperplasia to hypertrophy determined by the ratio proteins/DNA occurred at day 18 of development. It is suggested that the activation of uridine phosphorylase activity during the early life of the rat may be a critical element of the onset of hypertrophy.
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