Abstract
This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity. PubMed, Cochrane Library, EMBASE and China Biology Medicine were searched up to March 1, 2020. Randomized controlled clinical trials of urate lowering therapy in hyperuricemia patients were included in meta-analysis. Effect size was estimated as mean difference with 95% confidence interval (CI). Our search yielded 7 eligible trials with 503 participants. This meta-analysis showed that uric acid-lowering therapy decreased fasting insulin -1.43 µIU/ml (weighted mean differences (WMD, 95% CI -2.78 to -0.09), homeostasis model assessment of insulin resistance -0.65 (WMD, 95% CI -1.05 to -0.24), systolic blood pressure -2.45 mm Hg (WMD, 95%CI -4.57 to -0.33) and diastolic blood pressure -3.41 mm Hg (WMD, 95%CI -3.87 to -2.95). However, the treatment had no significant effect on fasting plasma glucose (WMD -0.19 mmol/L, 95%CI -0.42 to 0.05), homeostasis model assessment of β-cell function index (WMD -0.02, 95%CI -0.28 to 0.24), total cholesterol (WMD 0.18 mg/dl; 95%CI, -1.39 to 1.75) and triglyceride (WMD 3.15 mg/dl, 95% CI -9.83 to 16.14). Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-β and serum lipids.
Highlights
Metabolic syndrome is a cluster physiological and anthropometric abnormalities of nutrients metabolism, such as hyperglycemia, hyperuricemia and hyperlipidemia1, 2
In this meta-analysis, we showed that urate lowering therapy (ULT) decreased homeostasis model assessment of insulin resistance (HOMA-insulin resistance (IR)), fasting insulin (FINS) and blood pressure (BP), but had no effect on fasting plasma glucose (FPG), homeostasis model assessment of β-cell function (HOMA-β) or serum lipids
It has been reported that serum levels of uric acid were increased with age9, 40-44 and hyperuricemic patients usually company with relatively higher central obesity, serum lipids and BP, which were closely associated with IR . 14, 15, 42, 45, 46
Summary
Metabolic syndrome is a cluster physiological and anthropometric abnormalities of nutrients metabolism, such as hyperglycemia, hyperuricemia and hyperlipidemia . The metabolism of three major nutrients are closely linked. Hyperuricemia could contribute to abnormal glucose metabolism, insulin resistance (IR), even pancreatic β-cell death. Substantial data from epidemiologic and experimental studies indicate an emerg-. African Health Sciences, Vol 21 Issue 1, March, 2021 asymptomatic hyperuricemia. We conduct a meta-analysis to investigate whetherLT might be helpful for diabetes patients
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