Uric acid levels on sub-chronic oral administration of Cassava leaf extract

Abstract

Cassava leaf one of herb in Indonesia needed the safety data to develop as herbal medicine. Cassava leaf contains carbohydrate, protein, flavonoid, triterpenoid, saponin, tannin, mineral, and vitamin C. The cassava leaf contained moderate purine potentially increasing the plasma uric acid. This study aims to analyze uric acid levels on plasma rat that given sub chronically cassava leaf extract. This research was an experimental posttest with control group design. The total of 36 adult rat was randomly divided into 4 groups. The experimental groups were treated Cassava leaf extract orally for 45 days. The doses were 80 mg/kg body weight (P1), 400 mg/kg body weight (P2) and 2000 mg/kg body weight. Peripheral blood was taken from orbital sinus in day 45, then was measured the uric acid level. The average of blood uric acid levels for all groups were K (1.27 mg/dL), P1 (2.13 mg/dL), P2 (1.38 mg/dL) dan P3 (1.43 mg/dL). All of values were in range of normal uric acid value for rat (1.7 - 3.0 mg/dL). The Anova analysis resulted that no difference uric acid level between control and experiment groups. We concluded that the sub chronic giving of cassava leaf extract of 80 mg/kg body weight, 400 mg/kg body weight and 2000 mg/kg body weight did not increase the uric acid levels on rat.