Abstract
Elevated serum uric acid has been associated to a variety of cardiovascular disease states and with systemic inflammation. The aim of this study was to analyze the association between uric acid levels and inflammatory markers in hemodialysis (HD) patients. This cross-sectional study included 50 HD patients (62% men, 54.3±12.6 yrs, BMI 24.4±4 Kg/m2) and 21 healthy individuals (45% men, 50.7±15.7 yrs, BMI 25.5±4.0 Kg/m2). Uric acid was measured using uricase-PAP method, inflammatory (TNF-α, IL-6 and CRP) and atherosclerosis markers (ICAM-1, VCAM-1, MCP-1 and PAI-1) were measured by a multiplexed particle-based flow cytometric assay. There was a positive correlation between serum uric acid and inflammatory markers, IL-6 (r=0.30, p=0.01), CRP (r=0.37, p=0.003), TNF-α (r=0.40, p=0.001) and adhesion molecules levels, ICAM-1 (r=0.53, p=0.0001), and VCAM-1 (r=0.45, p=0.0001)ParametersHD PatientsHealthy individualsCRP (mg/mL)0.32 ± 0.30*0.11 ± 0.12TNF-α (pg/mL)5.5 ± 2.1*2.4 ± 1.1IL-6 (pg/mL)4.1 ± 1.6*2.7 ± 0.4PAI-1 (ng/mL)7.0 ± 2.76.2 ± 2.1MCP-1 (pg/ml)47.6 ± 24.237.3 ± 19.0VCAM-1 (ng/mL)48.5 ± 8.5*23.8 ± 5.5ICAM-1 (ng/mL)20.5 ± 15.9*7.2 ± 1.2⁎p<0.05 p<0.05 In conclusion, these original data suggest that uric acid may have a role in inflammation and atherosclerosis in HD patients
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
