Abstract
The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults. However, whether these relationships exist in adolescents is unknown. We randomly selected 8,005 subjects who were between 10 to 15 years old at baseline. Measurements of uric acid were used to predict the future occurrence of metabolic syndrome, hypertension, and type 2 diabetes. In total, 5,748 adolescents were enrolled and followed for a median of 7.2 years. Using cutoff points of uric acid for males and females (7.3 and 6.2 mg/dl, respectively), a high level of uric acid was either the second or third best predictor for hypertension in both genders (hazard ratio: 2.920 for males, 5.222 for females; p<0.05). However, uric acid levels failed to predict type 2 diabetes mellitus, and only predicted metabolic syndrome in males (hazard ratio: 1.658; p<0.05). The same results were found in multivariate adjusted analysis. In conclusion, a high level of uric acid indicated a higher likelihood of developing hypertension in both genders and metabolic syndrome in males after 10 years of follow-up. However, uric acid levels did not affect the occurrence of type 2 diabetes in both genders.
Highlights
The clustering of overweight, high blood pressure, high blood glucose and dyslipidemia has previously been reported, which is important because of the close relationships with cardiovascular diseases (CVD) and type 2 diabetes (DM) [1,2]
The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, type 2 diabetes mellitus, and hypertension have been studied in adults
Measurements of uric acid were used to predict the future occurrence of metabolic syndrome, hypertension, and type 2 diabetes
Summary
The clustering of overweight, high blood pressure, high blood glucose and dyslipidemia has previously been reported, which is important because of the close relationships with cardiovascular diseases (CVD) and type 2 diabetes (DM) [1,2]. Due to the ‘endemic’ nature of these modern diseases, the way to identifying subjects at risks has become increasingly important. In 2003, the World Health Organization published the definition of metabolic syndrome (MetS) [3]. The International Diabetes Federation consensus report for definition of the MetS for children and adolescents in 2007 is the most well recognized [4]. Nowadays in Asia, life style has been dramatically westernized. The consequence of this change is the increase of PLOS ONE | DOI:10.1371/journal.pone.0143786. The consequence of this change is the increase of PLOS ONE | DOI:10.1371/journal.pone.0143786 November 30, 2015
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