Abstract
ObjectiveMounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD.Materials and MethodsThere were altogether 127 VD subjects and 81 nondemented controls enrolled in our study. Serum UA, demographic, and clinical characteristics were recorded at baseline, and all participants underwent Mini‐Mental State Examination (MMSE) at the beginning of the trial.ResultsThe VD group showed lower MMSE scores and serum UA levels than nondemented controls and there was significant statistical difference between the two groups (p < .05). Demographic and clinical characteristics such as age, gender, education, body mass index (BMI), total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL), low‐density lipoprotein cholesterol (LDL), blood urea nitrogen (BUN), and serum creatinine (Scr) did not differ dramatically between groups (p > .05). In VD subjects, there was a positive correlation between serum UA and MMSE scores (r = .32, p < .05), and this correlation was independent of demographic and clinical characteristics (β = .272, p < .05).Conclusions VD subjects have dramatically lower serum UA levels in comparison to nondemented controls. Lower serum UA levels are linked to cognitive dysfunction and could serve as a potential predictor for VD.
Highlights
As reported by the World Health Organization, approximately 35.6 million people are suffering from dementia and the figure is anticipated to have a twofold increase by 2030 and more than a threefold increase by 2050 (Foltyn, 2015).Vascular dementia (VD), one of leading dementia only second to Alzheimer’s disease (AD), is accounting for no
The result suggested that vascular dementia (VD) patients have significant lower Mini-Mental State Examination (MMSE) scores, in addition with reduced serum Uric acid (UA) levels
Our study indicated that reduced serum UA levels might contribute to the pathogenesis of VD and there existed a possible link between VD and serum UA levels
Summary
As reported by the World Health Organization, approximately 35.6 million people are suffering from dementia and the figure is anticipated to have a twofold increase by 2030 and more than a threefold increase by 2050 (Foltyn, 2015).Vascular dementia (VD), one of leading dementia only second to Alzheimer’s disease (AD), is accounting for no
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
