Uric Acid in Cardiovascular Diseases: A Factor or an Incident?

Lucretia Anghel ,Adrian Beznea ,Anca-Iulia Neagu ,Gabi Topor ,Cristian Onisor ,Silvia Fotea

doi:10.37358/rc.19.12.7773

Abstract

The pathophysiological involvement of uric acid in cardiovascular disease has been intensively addressed in the last decades by the medical community. The tendencies to elucidate its role in cardiac events have been carried out in numerous researches with controversial results. In an attempt to understand this phenomenon, the existence of a paradox is admited, according to which uric acid behaves as an antioxidant, capturing reactive oxygen species, and in the context of an existing cardiac pathology, manifests a precipitating oxidative effect of circulating lipids, there being also present. inflammatory substrate. The involvement of the target organs in hypertension, along with other factors such as hyperlipidemia, obesity, pathologies of the valvular apparatus, contributes to the appearance of hyperuricemia of excretory cause. The ability of xanthine oxidoreductase to produce reactive oxygen species that contribute to the occurrence of oxidative stress and endothelial dysfunction has redirected our visions to a more complex approach to ischemic heart disease. And the use of xanthine oxidoreductase inhibitors in cardiovascular disease in patients with hyperuricemia has allowed to appreciate real benefits in improving renal function and preventing atherosclerosis. Keywords: uric acid, cardiovascular disease, factor

Highlights

The pathophysiological involvement of uric acid in cardiovascular disease has been intensively addressed in the last decades by the medical community
The uric acid concentration varies from organ to organ, but there is an assumption that liver produce the largest amount, and excretion may be in the main in kidneys (70%), and intestines
The physiological balance of uric acid level is maintained by enzymes involved in the synthesis, conversion and degradation of purine compounds: 5′-Nucleotidase, adenosine deaminase, xanthine oxidase (XO), purine nucleoside phosphorylase

Summary

Introduction

The pathophysiological involvement of uric acid in cardiovascular disease has been intensively addressed in the last decades by the medical community. Having a predictive role: adolescents with a high concentration of uric acid associate the risk of further development of hypertension [16], and the cardiovascular mortality rate is increased [17]. 20] suggest a beneficial effect, believing that increased serum levels are a response to oxidative stress, inflammatory substrate, in cardiovascular disease, and that uric acid represents a nitric oxide generator.

Results

Conclusion