URIC ACID AND OXIDATIVE STRESS IN NON-SMOKING METABOLIC SYNDROME PATIENTS: PP.34.422

Abstract

Substantial evidence suggests that serum uric acid is an important, independent risk factor for cardiovascular and renal disease especially in patients with hypertension, heart failure, or diabetes. Oxidative stress alters the plasma lipoprotein profile, the coagulative parameters, the endothelium and the cell membranes. Aims: To investigate uric acid, oxidative stress, hs C-reactive protein and classical cardiovascular risk factors, in a non-smoking hypertensive adult patients group (TA:154.1 ± 12.5/91.2 ± 8.52mmHg; age:58.24 ± 6.33years) with/without MetS vs smoking hypertensive adult patient (TA:156.42 ± 20.5/92.85 ± 6.98mmHg; age:51.42 ± 4.96 years) with/without MetS and age-,sex-matched control group. Methods: We analyzed spectrophotometrically the concentration of serum and erythrocyte superoxiddismutase, catalase and malonaldialdehyde, ceruloplasmin. All the other risk factors (uric acid, fasting glucose, lipid profile, hsCRP) were assessed by validated standard procedures. Results: Plasma levels of oxidative stress parameters determined and CRP are significantly higher than the control group(p < 0.0001). There are no significant statistical differences between the smoking and the non-smoking groups apart from the number of the MetS inclusion criteria (2.57 ± 0,97 vs 3.62 ± 1,11,p = 0.029,α=0.05) and age (51.42 ± 4,96 vs 58.24 ± 6.33 years, p = 0.012,α=0.05). Oxidative stress markers in non-smoking hypertensive group are strongly correlated (r>0.7) with the number of criteria for MetS and CRP, they have an average correlation with age, weight, BMI, waist, fasting glucose, triglyceride, HDL-C and are not correlated with BP values. The coefficient of determination is significantly increased between the number of criteria for the MetS and oxidative stress parameters. Uric acid levels are correleted on average with weight, BMI, average BP, diastolic BP and erythrocyte SOD and CAT. Level of CRP activity is strongly correlated with the number of criteria for MetS, fasting glucose, oxidative stress markers and has an average correlation with TG,HDL-C. Conclusions: Increase oxidative stress activity and CRP levels are associated with MetS,but not with BP values. Oxidative stress activity is influenced by systolic BP, fasting glucose, TG,HDL-C,LDL-C, total-C, number of criteria for MetS. Uric acid activity is influenced by diastolic BP, weight. CRP levels are strongly influenced by age, waist, HDL-C. Clinical utility of oxidative stress for prediction of cardiovascular risk has to be explored in future studies. Part of this investigation was supported by the Romanian Research Grant (Project ID-1472/2008).