Abstract
Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency areso promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Thoseknowledges will enable further study is improving secondary metabolite production in the laboratory. In nature,secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea waterand microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondarymetabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensingmechanism
Highlights
Cribrostatin Eukariot Acetylenic CMikroba berasosiasi dengan spons menghasilkan suatu metabolit sekunder yang berperan dalam sistem pertahanan spons; 3
Marine microorganism is one of biologically active potential resources of secondary metabolites
Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied
Summary
Mikroba berasosiasi dengan spons menghasilkan suatu metabolit sekunder yang berperan dalam sistem pertahanan spons; 3. Spons dapat juga menghasilkan metabolit sekunder berupa protein yang dapat menahan pertumbuhan bakteri (perlindungan dengan sistem imun), contohnya adalah perforin (Thakur et al, 2003) dan tachylectin (Schroder et al, 2003). Bakteri yang hidup pada permukaan sel inang spons menghasilkan metabolit sekunder spesifik untuk melawan bakteri tertentu (perlindungan tidak langsung), contoh senyawa antifouling (Thakur et al, 2003) dan senyawa tribromophenol (Clare et al, 1999). Kondisi lingkungan dengan nutrisi terbatas menyebabkan penggunaan karbon oleh mikroba laut dalam metabolisme selular tidak digunakan untuk pertumbuhan sel melainkan karbon yang tersedia akan digunakan untuk produksi metabolit sekunder.
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