Abstract
This test relies on Cannon’s hypothesis that a denervated organ becomes hypersensitive to its neurotransmitter. Since the urethra is primarily an alpha-adrenergic organ, its denervation should produce a hypersensitivity to alpha-adrenergic stimulants. This hypersensitivity should be reflected in a higher urethral pressure in the urethral closure pressure profile after administration of the drug compared to the baseline urethral pressure. The drug used in testing is ethylphenylephrine in a usual dosage of 4 mg IV. Urethral closure pressure profiles are obtained before and after its administration for comparison. An increase of 15 cmH20 is considered positive and evidence of denervation of the urethra.
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