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Abstract
Urea transporter mRNA in papilla and pelvic epithelium of kidney in normal and low protein fed sheep
Highlights
The amount and distribution of the renal urea transporters (UT) varied among species
The deduced amino-acid sequence shared 92 and 93% identity with UT-A2 protein from rabbit and rat, and from human, respectively. This sequence analysis indicates that we have cloned a cDNA corresponding to part of sheep UT-A (GenBank accession number = AY303685)
UT-A mRNA expression was significantly lower in pelvic epithelium than in papillary tissue in NP ewes (2024±260 vs 5447±1040 molecules; P
Summary
The amount and distribution of the renal urea transporters (UT) varied among species. One reason for this variability is thought to be the dietary protein supply, the abundance of UT reflecting the adaptation (nitrogen salvaging) to differences in dietary protein, herbivorous having more diluted protein intake than omnivorous (Hediger et al, 1996). The advantage of this adaptation should be relevant in ruminants in which endogenous urea serves as nitrogen source for protein synthesis in their forestomachs. The aims of this work were a. the identification and cloning of a cDNA encoding an urea transporter in papilla and upper pelvic epithelium of sheep kidney and b. the comparison of the expression of urea transporter mRNAs in these structures in normal and low protein fed sheep
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