Abstract
Urate levels may be a marker of oxidative stress. The aim of the present study was to find out are there any differences in urate concentrations in exhaled breath condensate (EBC) between children with obstructive sleep apnea (OSA) and healthy children. EBC was collected in children with obstructive sleep apnea (OSA) and clinically healthy children. Urate measurements in EBC and serum were performed by enzymatic color test. The higher concentration of urates in EBC of children with OSA than clinically healthy children indicate the oxidative stress in their airways. Since there was no significant difference in serum concentration of urates between children with OSA and healthy children, it could be considered that urates are sintetized in the airways of children with OSA. The present study indicated that urates in EBC (but not in serum) may be used as a marker of local synthesis of antioxidant compounds, but definitive conclusion must be supported by investigations involving larger number of participants.
Highlights
Obstructive sleep apnea, obstructive sleep apnea (OSA), is disorder characterized by repeated episodes of apnea and hypopnea during sleep
The higher concentration of urates in exhaled breath condensate (EBC) of children with OSA than clinically healthy children indicate the oxidative stress in their airways
Since there was no significant difference in serum concentration of urates between children with OSA and healthy children, it could be considered that urates are sintetized in the airways of children with OSA
Summary
Obstructive sleep apnea, OSA, is disorder characterized by repeated episodes of apnea and hypopnea during sleep. It is a common disorder in pediatric population, affecting 2 to 3% of all children [1]. OSA is related to increased upper airway resistance. OSA is associated with the presence of adenotonsillar hypertrophy, septal deviation or macroglosia [3,4]. Recurrent episodes of airway obstruction are associated with decreased partial pressure of oxygen and decreased oxygen hemoglobin saturation during sleep, and with hypoxia and tissue damage. The aim of the present study was to find out are there any differences in urate concentrations in exhaled breath condensate (EBC) between children with obstructive sleep apnea (OSA) and healthy children
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