Abstract
AbstractRat peritoneal mast cells, when incubated in histamine‐H3containing medium, were shown to take up and concentrate histamine. The uptake was proportional to incubation time and to extracellular histamine concentration. Metabolic inhibitors did not significantly affect the uptake. The exogenous histamine was bound to mast cell granules in about the same proportion as found for the endogenous. Treatment of mast cells with compound 48/80 released the same relative amounts of both exogenous and endogenous histamine. These results suggest that histamine was taken up by passive diffusion and stored in the mast cell granules. High concentrations of 5‐HT inhibited the histamine uptake, whereas histidine and 5‐HTP did not influence the process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
