Abstract

AFTER oral administration of radioactive iodine, the uptake of the tracer by the thyroid gland is abnormally high in most cases of untreated hyperthyroidism (1, 2, 3). However, a significant overlap exists between the normal range of uptake and the range in hyperthyroidism (4, 5); cases with uptakes in the range of overlap must be considered borderline. Since it is in these borderline cases that the clinician has most difficulty in establishing the correct diagnosis, any safe procedure which would reduce the area of overlap would be welcome. It seemed desirable to determine if this purpose might be accomplished by administering the tracer intravenously, thereby eliminating the variables of rate and amount of gastrointestinal absorption. It was also hoped that the intravenous method would offer the additional advantages of rapidity and convenience.

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