Abstract
In a study of the biosynthesis of biotin in microorganisms it was observed that pimelic acid had no stimulatory effect on biotin production in Escherichia coli. By comparison Pseudomonas denitrificans was shown to produce significantly higher levels of biotin when grown in the presence of pimelic acid. The use of 1,7-14C-pimelic acid demonstrated that the uptake of the radioactive compound by P. denitrificans occurred rapidly whereas the uptake was negligible in E. coli. The permeability block to pimelic acid can explain the non-stimulatory effect of this compound on biotin production by E. coli.
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