Abstract
ABSTRACT This study was undertaken to determine whether the erythrocyte uptake of I131-l-triiodothyronine is affected by various erythrocyte abnormalities and whether consistent variations occur in association with several abnormal hematologic conditions. Plasma protein-bound iodine levels were determined in most cases in an attempt to rule out unsuspected thyroid disease. Normal I131-l-triiodothyronine uptake Aalues ranged from 10.58 to 18.34 per cent. In 3 cases of sickle-cell trait, normal values were observed, whereas in 2 pregnant patients with the trait, uptake values were low. Normal uptakes were also recorded in 1 case of sickle-cell anemia, 1 of sickle-cell thalassemia and 3 of thalassemia trait. Varying results were obtained in 9 cases of hemolytic anemia; in 2 cases associated with acute leukemia the uptakes were elevated despite very low hematocrits; in 3 cases associated with Hodgkin's disease, normal uptakes were noted in 2 and an increased uptake in 1; values were normal in a case of congen...
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