Abstract
Rabbit polymorphonuclear leukocytes have a saturable 3H-cortisol uptake in vitro , half saturated around 3 × 10 −9M cortisol. The ability of 28 other non-radioactive steriods, mainly glucocorticoids, to depress the saturable 3H-cortisol uptake was also studied. Among glucocorticoids in clinical use triamcinolone acetonide and paramethasone were the most potent, 5–6 and 5 times cortisol respectively, while dexamethasone was only twice as potent as cortisol. The cortisol stereoismer, 11-epicortisol, which has no glucocorticoid activity in vivo , had very little depressing potency. For the group as a whole a highly significant rank correlation was found between the depressing potency and the in vivo glucocorticoid potency obtained from the literature (and determined in rats or mice). Rabbit polymorphonuclear leukocytes thus have a specific cortisol uptake, probably corresponding to an interaction with a glucocorticoid receptor.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
