Abstract
A method and mathematical equation for determining the continuous uptake and release of serotonin during 60 minutes by platelets adhering to a polymer surface are presented. Heparinized human blood with autologous 51Cr and 14C-serotonin labelled platelets was exposed to the polymer in Chandler loops rotated slowly for different periods. Initially adhering platelets take up serotonin from non-adhering aggregating platelets and then slowly begin to release serotonin. Acetylsalicylic acid treated platelets adhere and take up serotonin to the same extent as untreated platelets, but do not undergo a release reaction.
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