Abstract
AbstractBioconcentration factors, uptake rate constants and elimination rate constants of a series of organophosphorous pesticides were determined in the guppy (Poecilia reticulata). The results of these three toxicokinetic parameters were related to measured octanol/water partition coefficients (Kow). A simple one‐compartment model fitted the uptake and elimination characteristics of the chemicals. A biphasic relationship was observed between log k1 (uptake rate constant) and log Kow, whereas elimination rate constants were inversely related to Kow. For some of the test compounds substantially higher elimination rates were found, compared to isolipophilic chlorobenzenes, which resulted in lower bioconcentration factors. This divergent behavior is discussed in view of possible biotransformation reactions for these compounds.
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