Abstract
This report on the literature spans from May to July, highlighting breakthroughs on several important genomes, including mouse, zebrafish, Fugu and Plasmodium. Recent papers have reported on a mechanism for genome size reduction in Arabidopsis, comparisons and verifications of large-scale protein–protein interaction datasets, developments in RNA interference approaches for mammalian systems and a solidphase peptide tagging method for proteomics.
Highlights
On 6 May the NIH- and Wellcome Trust-funded International Mouse Genome Sequencing Consortium (IMGSC) announced that they had produced a draft of the mouse genome (Sanger Institute IMGSC Press Release)
This project has benefited from knowledge gained and technological improvements that occurred as a result of the Human Genome Sequencing Project, being completed much more swiftly, in around a year
Using the mouse data to aid in the finishing of the human genome should speed up that process, allowing the team to complete the human genome in time for the 50th anniversary of Crick and Watson’s discovery of the structure of DNA, in April year
Summary
They predict that the ∼8.65 Mb linear chromosome (the largest bacterial genome to be completely sequenced so far) contains 7825 genes. Combining the data from the EST database and the six sequenced BACs led to the prediction that the tomato genome encodes ∼35 000 genes.
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