Abstract
This manuscript constitutes a commentary on: “Retrospective cohort study of long-term outcomes and prognostic factors for survival after lower extremity amputation in patients with diabetes” by Vuorlaakso et al. (2023). We aim to contribute to the reflection of their findings to support the comprehensive management of vulnerable individuals with multimorbidity and/frailty for limb preservation. There is an urgent need to understand the effects of frailty on overall survival after amputation, survival without major amputation, and the effect modification with multimorbidity.
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