Abstract
γ-oscillatory activity is ubiquitous across brain areas. Numerous studies have suggested that γ-synchrony is likely to enhance the transmission of sensory information. However, direct causal evidence is still lacking. Here, we test this hypothesis in the mouse olfactory system, where local GABAergic granule cells (GCs) in the olfactory bulb shape mitral/tufted cell (MTC) excitatory output from the olfactory bulb. By optogenetically modulating GC activity, we successfully dissociate MTC γ-synchronization from its firing rates. Recording of odor responses in downstream piriform cortex neurons shows that increasing MTC γ-synchronization enhances cortical neuron odor-evoked firing rates, reduces response variability, and improves odor ensemble representation. These gains occur despite a reduction in MTC firing rates. Furthermore, reducing MTC γ-synchronization without changing the MTC firing rates, by suppressing GC activity, degrades piriform cortex odor-evoked responses. These findings provide causal evidence that increased γ-synchronization enhances the transmission of sensory information between two brain regions.
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