Abstract
Aim: To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM).Methods: High-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients and controls.Results: It was found for the first time that lncRNA NR_046683 is closely related to the prognosis of MM. It was also detected in tumor cell lines KM3, U266, especially in drug-resistant cell lines KM3/BTZ and MM1R. The NR_046683 expression differed significantly in patients of different MM subtypes and staging. Moreover, the overexpression of NR-046683 is closely related to β2-microglobulin. We also found that the overexpression of NR-046683 correlates to chromosomal aberrations, such as del(13q14), gain 1q21, and t(4;14).Conclusion: lncRNA NR_046683 can serve as a novel biomarker for potential drug target and prognostic prediction in MM.
Highlights
Multiple myeloma (MM) is a hematologic malignancy caused by the proliferation of plasma cells in bone marrows
Specialty section: This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
MM usually develops from monoclonal gammopathy of under determined significance (MGUS) (Weiss et al, 2009; Kyle and Rajkumar, 2010)
Summary
Multiple myeloma (MM) is a hematologic malignancy caused by the proliferation of plasma cells in bone marrows. MM is the second most common cancer of blood system after non-Hodgkin lymphoma, and is associated with the signs and symptoms of bone pain, pathologic fractures, hypercalcemia, anemia, and renal failure C. et al, 2017; Cowan et al, 2018). The development from MGUS to MM is accompanied by genetic variations such as cytogenetic aberrations, primary or secondary chromosomal translocation and oncogene activation. Understanding these genetic variations is of high importance for prognostic and response prediction
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