Abstract
BackgroundGrowing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients.MethodsThe expression of lncRNA BANCR was measured in 106 CRC tissues and 65 adjacent normal tissues using the quantitative real-time PCR.ResultsThe study showed that lncRNA BANCR was highly expressed in CRC tissues compared with adjacent normal tissues (P < 0.001). In addition, high expression of lncRNA BANCR was positively correlated with the lymph node metastasis (P < 0.001). Kaplan–Meier analysis showed that patients with high lncRNA BANCR expression had a shorter overall survival (OS) compared with the low lncRNA BANCR expression group (P = 0.001). Interestingly, for the group of patients with the lymph node metastasis, we found the similar result that high lncRNA BANCR expression was related to poor OS (P = 0.004). Furthermore, the multivariate Cox regression model analysis indicated that high expression of lncRNA BANCR was an independent poor prognostic factor in CRC patients (HR 2.24, 95% CI 1.22–4.16, P = 0.009).ConclusionsUpregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of CRC. LncRNA BANCR could be served as a novel and useful biomarker for CRC lymph node metastasis and prognosis.
Highlights
Growing evidence has supported that long non-coding RNAs could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC)
LncRNA BRAF-activated non-coding RNA (BANCR) expression increased in CRC tissues In order to assess the effect of long non-coding RNAs (lncRNAs) BANCR in CRC, we firstly measured the expression levels of lncRNA BANCR in all 65 CRC tissues and 65 adjacent normal tissues
The relationship between lncRNA BANCR expression and clinicopathological features in CRC patients To further investigate the relationship between lncRNA BANCR expression and CRC clinicopathological features, we classified 106 CRC tissues into high and low lncRNA BANCR expression groups according to the median value of all samples
Summary
Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). Little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients. Colorectal cancer (CRC) is the third most common malignant tumor and one of the leading causes of cancerrelated deaths worldwide, making CRC a major public health problem all over the world [1]. Long non-coding RNAs (lncRNAs), which are a class of non-coding RNAs with length more than 200 nucleotides, are being paid more and more attention due to its critical role in the transcriptional, epigenetic, and post-transcriptional regulation of gene expression [5, 6]. A number of studies have investigated the aberrant expression of lncRNAs in CRC tissues and indicated that lncRNAs might serve as potential prognostic biomarkers and therapeutic targets [13,14,15]
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