Abstract
Upregulation of hnRNPC1/C2 expression in preeclampsia: a potential rationale for vitamin D insensitivity Preeclampsia, a pregnancy-specific disorder in humans, is characterized by newly-onset maternal hypertension and proteinuria after 20 weeks of gestation. This pregnancy disorder complicates 5-8% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality worldwide. Preeclampsia is also a predisposing factor for cardiovascular and kidney diseases in women later in life. Although the etiology of preeclampsia is heterogenous, epidemiological studies revealed that vitamin D deficiency is a risk factor for preeclampsia development. Here, Drs Yuping Wang and David F. Lewis from Louisiana State University Health Sciences Center – Shreveport discuss hnRNPC1/C2 upregulation, a potential rationale for vitamin D insensitivity.
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