Abstract
Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H 2O 2. We report the first proteomic study of microsomal proteins in the context of H 2O 2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H 2O 2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane.
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